A special type of chromosome 1 abnormality in myelodysplastic syndrome patients: duplication 1q
نویسندگان
چکیده
منابع مشابه
Giemsa banding pattern of a heritable 1q+ variant chromosome: a possible partial duplication.
One morphological variant of chromosome 1 in man differs from the more usual form of this chromosome in being longer and more submetacentric. This is due to increased length of the long arm and because there is apposition of chromatids in the paracentromeric region of the long arm (q). This variant, or similar appearing variants ofchromosome 1, have been found in 1 per 100 to 1 per 1000 newborn...
متن کاملInversion of chromosome 7q22 and q36 as a sole abnormality presenting in myelodysplastic syndrome: a case report
INTRODUCTION Deletions of chromosome 7 are often detected in myelodysplastic syndrome. The most commonly deleted segments are clustered at band 7q22. A critical gene is therefore suggested to be located in this region. We report a patient with myelodysplastic syndrome whose marrow cells carried an inversion of 7q22 and q36 as a sole karyotypic abnormality. How this extremely rare chromosomal ab...
متن کاملmyelodysplastic syndrome with 6q deletion as the sole chromosome abnormality in an iranian patient: a case report with review of literature.
the myelodysplastic syndrome (mds) is a highly heterogenous disorder and karyotype analysis is helpful for diagnostic and prognostic estimation. deletion in long arm chromosome 6 (6q del) as a sole abnormality is a rare event in mds. this is the first case report of del (6q) as the only observed diagnostic change in iran. we also reviewed the literature of this cytogenetic lesion.
متن کاملNew recurrent chromosome change in pediatric therapy-related myelodysplastic syndrome: unbalanced translocation 1/6 with cryptic duplication of short arm of chromosome 6.
The incidence of therapy-related myelodysplastic syndrome (t-MDS) in pediatric patients is increasing in parallel with the more successful management of the primary tumor, but scant information is available on clinical and cytogenetic characteristics. We report here two children affected by t-MDS after chemo/radiotherapy for a primary solid tumor, both with an unbalanced translocation 1/6 in th...
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ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 2020
ISSN: 0007-1048,1365-2141
DOI: 10.1111/bjh.16643